This dual-receptor action typically produces stronger appetite suppression and faster weight loss, which is why tirzepatide often works for patients who plateau on semaglutide alone
What to expect during the switch: 7-day gap: Stop Mounjaro on your normal injection day, then wait 7 days before starting Wegovy Starting fresh: Begin with the lowest Wegovy dose (0.25mg) regardless of your previous Mounjaro dose Gradual increase: Your dose will be increased every 4 weeks as tolerated Side effects may return: Mild nausea, stomach upset, or changes in appetite are normal initially Timeline: Week 1: Final Mounjaro dose Week 2: No medication (washout period) Week 3: Start Wegovy 0.25mg Weeks 3-6: Continue 0.25mg weekly Weeks 7-10: Increase to 0.5mg if tolerated Continue: Following the standard Wegovy dose schedule Wegovy Dose Escalation Schedule Following the 7-day washout period, you'll start Wegovy at the lowest dose and gradually increase according to the established titration schedule: Weeks 1-4 (of Wegovy treatment): 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Weeks 13-16: 1.7 mg weekly Week 17 onwards: 2.4 mg weekly (maintenance dose) This methodical approach allows your body to adapt progressively, minimising potential side effects and maximising treatment tolerability
Does the TB-500 blend require different handling
Georgieva A, Cate H, Keulen E, van Oerle R, Govers-Riemslag J, Hamulyak K, van der Kallen C, Van Greevenbroek M, De Bruin T
