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Despite their efficacy, long-term LD use is associated with motor complications, prompting the development of novel therapies such as adenosine A2A antagonists (istradefylline), which reduce OFF episodes, and GLP-1RAs, which show neuroprotective potential

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Systemic inflammation and remote organ injury following trauma require HMGB1

For subcutaneous and intramuscular peptide injection, both contraindications are non-issues the SubQ/IM route is what the product is designed for