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The compound is derived from a sequence associated with gastric protective proteins, which has made it a subject of interest across a broad range of preclinical research models

Many factors can contribute to GERD, including obesity, diet, and certain medications

Chronic hypoxia drives the conversion of Tregs to pro-inflammatory Th17 cells via the HIF-1 pathway, characterized by reduced CD25 expression, increased OX40 expression, and exhaustion of immunosuppressive function, which exacerbates Th1/Th17 cell polarization and the release of pro-inflammatory factors such as IL-17A and IFN- (Lantz et al., 2024)