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Jun Yin, Jianping Ye, Weiping Jia: Effects and mechanisms of berberine in diabetes treatment, Acta Pharmaceutica Sinica B, Volume 2, Issue 4, 2012

Namely: Reduction in gaining lean muscle mass whilst on an exercise program, compared to placebo 5 Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, doubleblind, placebocontrolled, multicenter trial: The MASTERS trial Walton et al (Sept 2019)

Both agents carry the same class warnings: boxed warning for thyroid C-cell tumors (rodent studies), risk of pancreatitis, and contraindication with personal/family history of medullary thyroid carcinoma or MEN 2 syndrome

For best results, use consistently as directed while maintaining healthy daily habits