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The companies that generate the best returns from the LOE cycle are those that see further ahead than their competitors identifying P.IV opportunities before competitors file, anticipating LOE events before they reach consensus estimates, and securing API supply chain relationships before generic launch day

10.1016/j.bcp.2024.116072 107 LuoX.WangY.ZhuX.ChenY.XuB.BaiX.et al (2024)

Forecasting models that only model volume share and not net price trajectory will produce numbers that are arithmetically precise and commercially useless

Conversely, modulating the composition of the microbiota using the probiotic VLS#3, stimulated production of butyrate, promoting GLP-1 secretion, and improving the metabolic state in mice (193)