Akira, K., Amano, M., Okajima, F., Hashimoto, T
We chose 2 cases in the high ACTL6A group and 2 cases in the low ACTL6A group for PDX experiment
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Phase 2 data (Jastreboff et al., NEJM 2023) showed mean pulse rate increases of approximately 3 to 5 beats per minute at higher doses, consistent with known GLP-1 receptor agonist pharmacology