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As such, perhaps the ability of the juvenile Cntnap2 KO mice to respond acutely to the MC4R agonist may be secondary to a critical time point in development with increased responsiveness to oxytocin stimulation and reward behaviors based on oxytocin receptor distribution

doi: 10.1111/joa.12258 [DOI] [PMC free article] [PubMed] [Google Scholar] 17

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Interestingly, NKCC1 KO mice also showed reduced satiation control to ad libitum feeding before developing overweight and a MetS-like phenotype (Rathod et al., 2023), consistent with the hypothesis that islets hormones participate in the control of food/energy intake (Woods et al., 2006)