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Distribution The mean volume of distribution at steady state following a single 100-mg intravenous dose of sitagliptin to healthy subjects is approximately 198 liters

The maintenance frequency approach offers middle ground where users completing intensive initial treatment (6-12 months daily) transition to reduced frequency (2-4 times weekly) maintaining copper supplementation at lower intensity and cost while avoiding complete discontinuation allowing some benefit decline

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August 21, 2025: Novo Nordisk to Pay an Estimated $2 Billion for Ozempic Lawsuits According to a recent analysis, Novo Nordisk may have to pay an estimated $2 billion in compensation for the lawsuits being filed against it