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What the labeling does say about timing is more useful and more specific: gastrointestinal adverse reactions "were most frequently reported during dosage escalation." The clock that matters is the escalation calendar, not the hour hand

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Current FDA-approved anti-amyloid antibody therapies for AD can result in adverse events that can be detected through magnetic resonance imaging (MRI) in the form of amyloid-related imaging abnormalities (ARIA) (Withington and Turner, 2022)

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Retatrutide remains an investigational medicine and has not yet received marketing authorisation from the MHRA or the EMA

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