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508,509 Clinical presentation of Rett syndrome often includes aberrant breathing patterns, which can be mimicked in mice by astrocyte-specific deletion of MECP2 , 510 whereas re-introduction of the gene rescued abnormal breathing

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[73,74] Other peptides derived from histone proteins have shown similar effects and have been investigated as therapeutic candidates in SLE, [75, 76, 77] including the phosphorylated spliceosomal epitope peptide P140, which represses B cell differentiation and protects against murine lupus

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