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Description

Semaglutide (Wegovy) FDA-approved for: Chronic weight management Treatment of Metabolic dysfunction-Associated Steatohepatitis (MASH) approved August 2025 FDA-indicated for: Reducing risk of heart attack, stroke, and cardiovascular death in adults with established cardiovascular disease who are obese or overweight Weekly injection Clinical trials show an average weight loss of 1215% of body weight

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51 HF hospitalisations were significantly reduced in patients with a preserved, but not reduced, ejection fraction

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(2) Microenvironment-informed targeting: The melanoma lymph node work suggests that in vitro drug response may underestimate efficacy because FSP1 dependence can be imposed by in vivo constraints 117

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