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In one study, researchers found that bilirubin significantly inhibited autophagy in the human colon adenocarcinoma cell lines of LS180 and SW480 cells by suppressing Beclin-1 and Microtubule-Associated Protein 1 Light Chain 3B (LC-3B) in the cells, and increased apoptosis by the upregulation of p53 in LS180 cells and downregulation of the Bcl-2 gene which inhibits apoptosis in SW480 cells (85)

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[4] BPC-157 also interacts with the dopaminergic and serotonergic systems in the central nervous system, modulates the hypothalamic-pituitary-adrenal axis, and has documented effects on growth hormone receptor expression

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