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While the estimates included possible savings from improved health, these were not nearly sufficient to offset the costs of the medications

The insulin resistance in PCOS might also occur independently of body weight, due to inherited post-receptor defects in insulin signalling that affects metabolism and mitotic pathways, not only in classic insulin target tissues, such as skeletal muscle, liver, and adipose tissue, but also in the non-classical target tissues, such as pituitary and ovary [12, 16]

[20]Sharma P, Dubey RS

The Psychological Layer That Follows Biology Theres one more dimension that rarely gets discussed