Key Preclinical Study (Neelakantan et al., 2018): Treatment in diet-induced obese mice produced progressive body weight loss, reduced white adipose tissue mass and adipocyte size, decreased total cholesterol, and no changes in food intake effects were metabolic, not appetite-driven
those switched to placebo regained about 14% over the next year. Weight loss slows toward a plateau on a held dose rather than continuing indefinitely
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