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At CIV, NO inhibits respiration by binding to its oxygen binding site and inhibiting the flow of electrons through the respiratory chain (decreasing complex activity) (Taylor and Moncada, 2010

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Particularly among patients with psychiatric comorbidities, adverse neuropsychiatric outcomes such as anxiety and mood changes have been observed, especially with cannabinoid receptor 1 antagonists and stimulants [26, 27]

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