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Some patients develop gallbladder problems, including gallstones or even gallbladder inflammation (cholecystitis), during treatment

Pre-workout supplements and GLP-1 medications like semaglutide or tirzepatide can both affect heart rate and blood pressure, requiring careful clinical consideration before combining them

SURPASS-2 results (40 weeks, type 2 diabetes): Tirzepatide 5 mg: -7.6 kg weight loss, -2.01% HbA1c reduction Tirzepatide 10 mg: -9.3 kg weight loss, -2.24% HbA1c reduction Tirzepatide 15 mg: -11.2 kg weight loss, -2.30% HbA1c reduction Semaglutide 1 mg: -5.7 kg weight loss, -1.86% HbA1c reduction SURMOUNT-5 results (72 weeks, obesity): Tirzepatide demonstrated statistically superior weight loss compared to semaglutide 2.4 mg

OConnor, T., Nguyen, M., & Patel, R