Several papers point to a preservation or increase in lean body mass.21 One even showed improvements in muscle composition (a decrease in muscle fat) in non-diabetic participants.27 Others have seen a reduction of lean body mass, making up around 20-50% of total weight lost, but its important to note that this was a review of research into several anti-diabetic drugs including some that arent GLP-1 RAs.26 Research into low-calorie diets reveals that exercise and a high protein intake can help preserve muscle mass and even build muscle while restricting calories, so you cant just eat junk, not exercise, and still expect these drugs to work miracles.22 Your overall health can improve by adding exercise and a healthy, protein-rich diet to a GLP-1 RA routine
Additionally, constipation can be an issue, affecting roughly 30% of people during early GLP-1 treatment, largely due to reduced fluid and fiber intake
Seek Professional Guidance : For more information on managing side effects of Semaglutide and personalized guidance on using this medication for weight loss, visit Identifying Potential Side Effects For anyone considering Semaglutide for weight loss, its necessary to understand the potential side effects that may arise during treatment
The SUSTAIN clinical trial programme evaluated semaglutide in various scenarios, including use alongside metformin
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