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While low levels of ROS are necessary for normal sperm functions such as maturation and fertilization, excessive ROS accumulationdriven by conditions like varicoceles, infections, or exposure to tobacco, alcohol, radiation, and environmental toxinscan lead to significant sperm damage

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European journal of endocrinology , 139 (5), 552561

Altogether, metabolomics offers a promising complement to existing biomarker strategies, supporting early diagnosis, differential classification of dementia subtypes, and possibly therapeutic stratification, provided robust algorithms and well-characterized cohorts are employed