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This unique glutamyl linkage distinguishes glutathione from typical peptides and contributes to its stability against common intracellular peptidases, which is important for both biological function and industrial handling

GSH in Cancer Dual Roles in Carcinogenesis and Drug Resistance (PubMed, 2019) Elevated Tumour GSH as a Driver of Chemotherapy Resistance A comprehensive review published on PubMed examined GSHs dual roles in cancer biology chemopreventive in normal cells through carcinogen detoxification by GST, and pathogenic in tumour cells where elevated GSH levels are associated with tumour progression and increased resistance to chemotherapeutic drugs and radiotherapy

The Cu 2 O 2 core lies on a plane created by the O atom of the caddie Tyr 98 and the N atoms of His 38 , His 190 , and His 216

He S, McPhaul C, Li JZ, et al