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It is also involved in numerous metabolic processes, including detoxification and energy production

3,4 This receptor and its agonists hold significant therapeutic potential, reshaping the treatment approaches for multiple diseases, including diabetes, cardiovascular disorders, and neurodegenerative diseases

It is not subject to feedback inhibition by GSH, and its substrates gamma-glutamylcysteine and glycine are rapidly ligated to form GSH

GHK (glycyl-L-histidyl-L-lysine) is a naturally occurring peptide found in human serum with levels averaging 200 ng/ml at age 20 but declining to an average of 80 ng/ml by age 60