Thus, the dual role of GLP-1RAs in reducing neurodegeneration by improving neuronal survival and modulating microglial activity, providing a potential therapeutic approach for neurodegenerative diseases (summarized in Fig
Clinical trial data show that gastrointestinal adverse effectsincluding nausea, vomiting, diarrhea, and abdominal discomfortoccur in 20-50% of patients initiating GLP-1 therapy, with rates varying by specific agent and dose
Dietary modifications form the cornerstone of managing Wegovy-related digestive symptoms: Increase fibre intake gradually through fruits, vegetables, whole grains, and legumes to promote regular, soft bowel movements Maintain adequate hydration (approximately 68 glasses of fluid daily) to prevent constipation and reduce dehydration risk Eat smaller, more frequent meals rather than large portions to reduce nausea and bloating Avoid high-fat, fried, or heavily processed foods that may exacerbate gastrointestinal discomfort Limit carbonated beverages that can increase bloating For constipation specifically , which poses the greatest theoretical risk for haemorrhoid development: Consider osmotic laxatives (e.g., macrogol) as first-line treatment, especially if bloating is present Bulk-forming laxatives (e.g., ispaghula husk) may be helpful but use cautiously if experiencing bloating Establish a regular toilet routine without prolonged sitting or straining Increase physical activity , which promotes intestinal motility Avoid constipating medications where possible (e.g., codeine, some antihistamines) Some patients find that adjusting medication timing helps manage symptoms, though this is not specified in the SmPC
According to the company website, this pricing includes provider consultations, prescription (if approved), medication, supplies, free expedited shipping, and 24/7 support access with unlimited messaging
.png)
