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But if fatigue, lethargy, and hypersomnia are central symptoms, it's often the SSRI I would want actively considered rather than dismissed as another antidepressant. When Lexapro is often the cleaner fit Lexapro tends to fit better when the mood picture includes: Persistent worry Physical tension Anxious rumination Restlessness Depression with a strong anxiety component These are the patients who often say, I don't need more energy