Multiple preclinical studies have demonstrated that co-targeting glycolysis and mitochondrial metabolism, or modulating key metabolic regulators such as AMPK, can significantly enhance the sensitivity of CRC cells to chemotherapy and targeted agents
CJC-1295 DAC Vials (5 mg each): 8 weeks (8 mg total) 2 vials 12 weeks (12 mg total) 3 vials 16 weeks (16 mg total) 4 vials Ipamorelin Vials (5 mg each): 8 weeks (56 days at ~200 mcg/day) 3 vials 12 weeks (84 days) 4 vials 16 weeks (112 days) 5 vials Insulin Syringes (U-100): Per week: 1 (CJC) + 7 (Ipamorelin) = 8 syringes 8 weeks: 64 syringes 12 weeks: 96 syringes 16 weeks: 128 syringes For Ipamorelin doses 10 units, 30- or 50-unit syringes improve accuracy
These drugs work by mimicking the action of natural GLP-1 hormone, which stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and reduces appetite
For example, a 2022 study in HFD-fed mice showed that 12-week liraglutide treatment markedly reduced the relative abundance of Bacillota , while increasing Bacteroidota , resulting in a marked decrease in the Bacillota/Bacteroidota ratio
