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Key points: In the only head-to-head trial, Wegovy produced 15.8% weight loss compared with 6.4% for Saxenda over the same 68-week period Wegovy 7.2 mg (approved January 2026) produces even greater results at 20.7% average weight loss Real-world data from Second Nature shows 19.1% weight loss with semaglutide when combined with behavioural support Semaglutide participants were nearly three times more likely to achieve at least 10% weight loss than liraglutide participants Side effects and tolerability Both medications share a similar side-effect profile, predominantly affecting the gastrointestinal tract

Weight Management Semaglutide and Tirzepetide injections have demonstrated exceptional results in supporting weight management

Meanwhile, GIP activation boosts how effectively your body processes sugar, maintaining healthy insulin levels

Retatrutide is still under clinical investigation and has not yet received full FDA approval for general medical use