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It is thought that the D2 receptor, in particular, may have neuroprotective effects in diseases such as epilepsy and ischemia [97]

It has been shown that tretinoin (retinoic acid) and its derivatives, isotretinoin, adapalene and tazarotene, may decrease pigmentation in vitro most probably via the induction of keratinocyte proliferation and epidermal turnover acceleration, rather than by acting directly on melanogenesis [145]

Prognosis and Long-Term Outlook With early intervention, most patients experience significant improvement in symptoms and function

Dhillon S (2021) Melphalan flufenamide (Melflufen): first approval