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TB-500 Maintenance Phase Dose How long: Weeks 5 to 12 (or weeks 7 to 12 if you ran the 6-week loading phase) Dose: 2 mg subcutaneous, once a week Some people taper to 2 mg every two weeks toward the end of the cycle, especially for acute injuries that are clearly improving by week 6

Most patients continue their metformin dose unchanged while beginning semaglutide, though your prescriber may adjust either medication based on your response after the first few weeks