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Abbreviation PI Paralytic ileus T2D Type 2 diabetes GLP-1RAs Glucagon-like peptide-1 receptor agonists MR Mendelian randomization GWAS Genome-wide association studies SGLT-2 Sodium-glucose cotransporter-2 HbA1c hemoglobin A1C GTEx Genotype-Tissue Expression IVW Inverse-variance weighted GRCh37 Genome Reference Consortium Human Build 37 Chr Chromosome EA Effect Allele NEA Non-Effect Allele NES Normalized Effect Size SE Standard Error OR Odds ratio LD Linkage Disequilibrium Footnotes Declarations The authors declare that they have no conflict of interest

Safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel non-bile acid FXR agonist tropifexor (LJN452) in healthy volunteers

Retatrutide is employing the same double-pronged approach

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