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For many, this is the most noticeable early change

The inhibition of GSK3 is likely a pivotal mechanism through which the therapeutic efficacy of Tanshinone IIA is mediated, as sodium nitroprusside, a known GSK3 activator, markedly counteracts its renoprotective benefits

The effectiveness and safety of 1G oral semaglutide has been further demonstrated in a real-world setting in the PIONEER REAL studies [42,43,44,45,46]