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Yet, GM has been reported to be capable of manipulating vitamin D activity either through upregulating VDR intestinal expression by producing short-chain fatty acid such as butyrate [107], or through competing it for VDR by lithocholic acid, a secondary bile acid [108]

The acetyl-CoA necessary for cytosolic fatty acid synthesis in cells in the brain, particularly oligodendrocytes (myelin producing cells), is derived from N -acetylaspartate (NAA), not from citrate as is the case for other tissues

Hofman, and M

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