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doi: 10.3389/fphar.2022.1004844 Received 27 July 2022 Accepted 24 October 2022 Published 08 November 2022 Volume 13 - 2022 Edited by Hartmut Jaeschke, University of Kansas Medical Center Research Institute, United States Reviewed by Zhenzhou Jiang, China Pharmaceutical University, China Pieter Annaert, KU Leuven, Belgium Updates Copyright 2022 Nsengimana, Okpara, Hou, Yan and Han

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Cells lining the airways and alveoli include epithelial cells and alveolar macrophages, the latter being resident innate immune cells important in surfactant recycling, protection against bacterial invasion and modulation of lung immune homeostasis

We have identified that mutations at Asp9 of glucagon (GCG) and GLP-1, as well as a GCGR/GLP-1R dual agonist, confer robust preference for cAMP production over -arrestin recruitment in vitro