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A subgroup analysis by weight reduction iced the case for proportionate benefit of symptom relief and less inflammation (by biomarkers) as a function of weight loss These are striking results for people with HFpEf given the only other drugs that have thus far shown benefit are the sodium-glucose cotransporter 2 (SGLT2) inhibitors

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To further confirm this observation, we transfected HepG2 cells with either scrambled siRNA or siRNA targeting GS overnight, followed by TNF challenge