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The FDA prescribing information for tirzepatide confirms that hypoglycemia is not a common adverse effect when the medication is used alone or combined with metformin, SGLT2 inhibitors, or thiazolidinedionesall medications that do not independently cause hypoglycemia

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In the latest JAMA Medical News podcast, Jennifer Abbasi interviews Rita Kalyani, MD, about investigational therapies including retatrutide, a triple agonist showing high efficacy for glycemic control and weight loss, and new oral options like orforglipron

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Functional and Clinical Relevance of Novel and Known PCSK1 Variants for Childhood Obesity and Glucose Metabolism. Molecular Metabolism, vol

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