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The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

Extracellular Matrix & Collagen Communication GHK-Cu is studied for its relationship with collagen regulation, elastin signaling, glycosaminoglycan synthesis, fibroblast activity, and extracellular matrix remodeling

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References: Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA