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Epub 2020 Dec 7..10.1016/j.idc.2020.10.007 [PubMed: 33303332] [CrossRef] 112

The article says slow escalation helps providers distinguish true hypersensitivity from expected adaptive side effects that resolve within one to two weeks

Sergey Terushkin, MD, FACS Gastrointestinal side effects are the main reason some patients consider stopping treatment early