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329 The number of osteoclasts was increased in GIPR-deficient mice and in vitro studies have shown that GIP suppresses the apoptosis of osteoblasts

At the lower doses used for diabetes, they have somewhat lower rates of diarrhea (9-12% for Ozempic, 12-21% for Mounjaro) compared to their weight management counterparts

There are other medication options that a skilled provider can prescribe for patients who cannot take GLP-1s. These include medications like phentermine or Qsymia and Contrave (a combination of Wellbutrin and naltrexone), which is especially helpful for emotional eating or cravings

Because testosterone and erections are both tied to the exact systems these drugs change: body fat, insulin sensitivity, and the health of your blood vessels