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In a Zucker diabetic fatty (ZDF) rat model, rosiglitazone reduced net -cell death, and increased -cell mass by levels almost twice that of the untreated control group [29]
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For instance, a retrospective observational study on hospitalized elderly patients with type 2 diabetes found that patients treated with GLP-1 receptor agonists combined with basal insulin had an increase in limb skeletal muscle mass, while those treated only with basal insulin showed a slight decrease, suggesting that under specific clinical management conditions, GLP-1 receptor agonists may help maintain muscle mass [61]
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