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19 The Effect of GLP-1RAs on Blood Pressure A meta-analysis of 16 RCTs showed that use of GLP-1RAs leads to a moderate BP reduction in patients with hypertension

These findings support the idea that some patients may have partial biologic resistance to incretin-based therapies, said Robert Glatter, MD, attending physician in the Department of Emergency Medicine at Lenox Hill Hospital in New York City, and Assistant Professor of Emergency Medicine at Zucker School of Medicine at Hofstra/ Northwell

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Incretin-based drugs are now being investigated and in some cases approved for a wide range of conditions, including cardiovascular disease, chronic kidney disease, sleep apnea, fatty liver disease (MASLD), neurodegenerative disorders, and even substance-use disorders