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In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) (14)

Significant predictors of new AF detection were female sex (odds ratio 1.47, 95% confidence interval 1.10-1.98), obesity (BMI30: 1.85,1.34-2.57), renal failure (2.08, 1.08-3.99), higher CHADS-VA score (1.27 per point increased, 1.15-1.41) and higher NIHSS score (5-15p: 1.43, 1.03-2.00

A: Yes, apply a small amount to clean skin morning and night as part of your skincare routine