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It also inhibits the Sirt1-Nrf2-Cyclin B1 axis and reduces Sirt1-dependent Chk2 acetylation, which disrupts spindle pole formation and causes chromosomal misalignment

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The daily oral dosing schedule also introduces adherence questions of a different kind

[DOI] [PubMed] [Google Scholar] 60.Ligumsky H, Wolf I, Israeli S, Haimsohn M, Ferber S, Karasik A, et al