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Flavonoid Metabolism: The Interaction of Metabolites and Gut Microbiota

In select cases particularly patients with: Obesity High insulin resistance Very high total daily insulin requirements endocrinologists may consider off-label use with: Continuous glucose monitoring Routine ketone monitoring Strict sick-day protocols Close specialist follow-up But this is not standard therapy

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7 In pancreatic -cells, GLP-1R activation by semaglutide enhances glucose catabolism and insulin secretion via the mTOR-dependent HIF-1 pathway, facilitating glycolysis and insulin release