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Boehringer Ingelheim's survodutide, a GLP-1/glucagon dual agonist without the GIP component, is a different shape of bet on the same hypothesis: that going beyond pure GLP-1 is where the next decade of obesity pharmacology lives

GLP-1 receptor agonists are a class of medicines that mimic the action of glucagon-like peptide-1 (GLP-1), a naturally occurring hormone in the human body

We further demonstrate that in female mice, sensitivity to the aversive properties of these drugs is estrous cycle-dependent, with responsiveness being amplified during proestrus, when circulating estrogen levels peak, and minimized during diestrus, when estrogen levels are low

Published 2022 Dec 13