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Therefore, different studies demonstrate that GS inhibition/downregulation can restrain tumor growth and resistance to radiotherapy and chemotherapy, suppressing glutamine-dependent nucleotide synthesis [5, 208,209,210,211,212]

Women are nearly twice as likely to develop anxiety disorders, potentially due to enhanced HPA axis activation under stress and modulatory effects of sex hormones on GABAergic and glucocorticoid signaling (Jaggar et al., 2020)

Additionally, computational techniques such as molecular docking and molecular dynamics simulations play a critical role in modern drug discovery and structural biology

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