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FMD measures the dilation of blood vessels triggered by the release of NO from endothelial cells in response to shear stress (307, 311)

placebo) Significant reductions in waist circumference a proxy for visceral fat, which is the metabolically harmful kind Improvements in fasting glucose and insulin resistance markers even in people without type 2 diabetes Early cardiovascular signal : reductions in blood pressure and lipids, though this is not yet the primary endpoint of ongoing trials Phase 3 trials are ongoing

Non-steroidal anti-inflammatory drugs activate NADPH oxidase in adipocytes and raise the H2O2 pool to prevent cAMP-stimulated protein kinase a activation and inhibit lipolysis

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