Concentrations greater than 850mg/L (6000micromol/L) are associated with severe poisoning .ref5 Correlation of Clinical Effects with VPA levels: 850mg/L: greatest risk for serious or life-threatening effects including coma, respiratory depression, metabolic acidosis, hypotension There have been cases of inaccurate valproate level measurements in severe overdoses because samples were not diluted before measurement write on the laboratory order form suspected valproate overdose and the likely ingested dose so that laboratory staff are aware
Eur Arch Otorhinolaryngol 254 Suppl 1: S911
Available from: Trial Registration Number: NCT02637284 Seiwerth S, Milavic M, Vukojevic J, Gojkovic S, Krezic I, Vuletic LB, Pavlov KH, Petrovic A, Sikiric S, Vranes H, Prtoric A, Zizek H, Durasin T, Dobric I, Staresinic M, Strbe S, Knezevic M, Sola M, Kokot A, Sever M, Lovric E, Skrtic A, Blagaic AB, Sikiric P
Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, et al