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Individual factors including concentration used, baseline skin condition, age, lifestyle, and complementary skincare significantly affect benefit retention creating substantial variation in personal outcomes requiring experimentation for determining optimal individual approach

Machine learning algorithms including SVM-RFE, LASSO, and Random Forest further confirmed LPCAT3 and PGD as potential diagnostic markers, and ROC curve analysis showed good discriminative performance

10.1016/j.cell.2017.10.011 Cell 407 RbU.StratmannK.HeinsenH.SeidelK.BouzrouM.KorfH

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