Even within the same tumor, some CSC clones can express high levels of drug efflux transporters, DNA repair enzymes, and antiapoptotic proteins, enabling them to survive treatment, whereas others cannot
J Immunother Cancer 4:111 Kind F, Michalski K, Yousefzadeh-Nowshahr E, Meyer PT, Mix M, Ruf J (2022) Bone marrow impairment during early [177Lu] PSMA-617 radioligand therapy: haematotoxicity or tumour progression
3 Ferroptosis and neurodegenerative diseases Iron is an essential trace element for maintaining brain function, playing vital roles in neuronal development, neurotransmitter synthesis, mitochondrial energy metabolism, myelin formation, and synaptic plasticity (Gao et al., 2025)
PMID: 30229898 Mukhopadhyay ND, Khorasanchi A, Pandey S, Nemani S, Parker G, Deng X, Arthur DW, Urdaneta A, Del Fabbro E (2024) Melatonin supplementation for Cancer-Related fatigue in patients with early stage breast Cancer receiving radiotherapy: A Double-Blind Placebo-Controlled trial