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The pivotal programs STEP for semaglutide ( The New England Journal of Medicine , 2021), SURMOUNT for tirzepatide (NEJM 2022), and SURMOUNT-OSA (NEJM 2024) studied distinct populations and endpoints

The triagonist IUB447 has shown superior efficacy compared with existing dual co-agonists and best-in-class mono-agonists in reducing body weight and improving glycaemic management in relevant rodent models

However, due to the projected significant cost revisions in the pricing of supply packs and because we did not propose to address supply pack pricing in the CY 2024 proposed rule, we stated in the CY 2024 final rule that this issue would be better addressed in future rulemaking

Commercially insured patients show a similar trend: 36% who began GLP-1 therapy in 2024 did not add another drug within a year, a significant rise from 13% in 2020