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Because of its missing SpyTag beta strand, the melting temperature of uncoupled SpyCatcher is much lower than after coupling with SpyTag 5

A spokesperson for Novo Nordisk confirmed that Ascendis TransCon (transient conjugation) technology is already used in the two commercial drug products Skytrofa (lonapegsomatropin) and Yorvipath (palopegteriparatide)

To combat this, the booster includes hyaluronic acid and N-Acetyl Glucosamine (NAG), along with amino acids, to deeply hydrate and support the skin's natural moisture barrier, reducing the likelihood of both dryness-induced acne and clogged pores