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Nojiri et al

Unlike a single-domain protein, recombinant multi-domain proteins are more likely to misfold or assemble in an incorrect 3D shape because of the interaction between their distinct domains

CPT1A knockdown reduced the expression of lymphangiogenic markers like Vascular endothelial growth factor receptor-3 (VEGFR-3) in HDLEC cells via acetyl-CoA-mediated Histone H3 lysine 9 acetylation (H3K9ac), which can be reversed by the addition of acetate (Xiong et al., 2018)