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These drugs mimic a hormone called GLP-1, which the gut naturally secretes in response to food and which binds to the hormones receptors around the bodyincluding in brain areas involved in appetite regulation and in reward pathways that reduce the pleasure response to food

Secretagogue models, by contrast, retain negative feedback from somatostatin and are unsuitable when the research question requires a non-pulsatile exposure profile

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Os medicamentos conhecidos como agonistas do receptor do peptdeo semelhante ao glucagon tipo 1 (GLP1) ganharam destaque pela capacidade de reduzir o apetite, controlar a glicemia e auxiliar no emagrecimento